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Top 5 NASDAQ Genetics Stocks (Updated March 2023)

Top 5 NASDAQ Genetics Stocks (Updated March 2023)



The genetics sector supports every other life science industry in a variety of ways.

One of its major contributions is the discovery of new genetic drivers of diseases. Genetic testing has grown substantially over the last few years thanks to advances in technology; growth has also been spurred by an increase in chronic diseases and the continuing development of test kits for therapeutic areas with unmet medical needs.

Gene therapy is also a huge driver of growth in the overarching genetics market. It’s estimated that in 2022 this market was worth US$7.54 billion, and according to Grand View Research it is expected to reach an impressive US$29.47 billion by 2030, growing at a compound annual growth rate of 19.1 percent over that time period.


This important sector of the life science market is focused on how genes can help treat or prevent serious conditions in patients. This includes the potential for healthcare professionals to implement gene therapy at the cellular level instead of using medication or surgery, replacing “faulty” genes with new ones to potentially cure diseases.

Pharma and biotech companies often dabble in genetics along with their core disciplines, meaning that some firms may also have operations in other areas. The top NASDAQ genetics stocks listed below have products related to gene therapy, genetic testing, genetically defined cancers and rare genetic diseases. Data for this list was collected on March 30, 2023, using TradingView’s stock screener, and the top NASDAQ genetics stocks are listed in order of best year-to-date performance.

1. Ambrx Biopharma (NASDAQ:AMA)

Year-to-date gain: 316.74 percent; market cap: US$387.73 million; current share price: US$8.96

Through its expanded genetic code technology platform, clinical-stage biopharma company Ambrx Biopharma is discovering and developing engineered precision therapies. The company’s portfolio of advanced clinical and preclinical programs is designed to improve efficacy and safety in the treatment of a number of cancer indications, such as prostate and breast cancers.

In March, Ambrx released positive results from a Phase 3 clinical study of its proprietary antibody-drug conjugate candidate ARX788, which was targeting HER2 positive metastatic breast cancer. The US Food and Drug Administration (FDA) has granted fast-track designation for ARX788 in HER2 positive metastatic breast cancer and orphan drug designation for ARX788 in gastric cancer, while China’s National Medical Products Administration has given ARX788 breakthrough therapy designations in breast cancer.

2. Biomea Fusion (NASDAQ:BMEA)

Year-to-date gain: 279.9 percent; market cap: US$945.99 million; current share price: US$31.95

Clinical-stage biopharmaceutical company Biomea Fusion’s proprietary FUSION System has allowed it to discover, develop and advance a pipeline of covalent-binding therapeutic agents targeting genetically defined cancers and metabolic diseases.

The company’s lead investigational drug candidate, BMF-219, is a covalent menin inhibitor with oncological and type 2 diabetes indications across three ongoing clinical trials: a Phase 1 study for its use in treating various leukemias, large B-cell lymphoma and multiple myeloma; a Phase 1/1b study for use in treating non-small cell lung cancer, colorectal cancer and pancreatic ductal adenocarcinoma; and a Phase I/II study for type 2 diabetes.

In 2023, Biomea Fusion plans to advance all three programs and deliver multiple clinical trial results throughout the year. Investors can also look forward to the advancement of its second product candidate, BMF-500, to clinical trials with an investigational new drug filing expected during the first half of the year.

3. Tempest Therapeutics (NASDAQ:TPST)

Year-to-date gain: 144.54 percent; market cap: US$24.71 million; current share price: US$2.91

Tempest Therapeutics is a clinical-stage oncology company advancing small-molecule therapeutics that modulate anti-tumor immunity pathways with the potential to treat a wide range of tumors. The company’s portfolio consists of clinical programs in various stages, from early research to investigational global studies.

Tempest is looking forward to a number of catalysts in 2023, including the release of data from a first-line randomized study with Roche Holding (OTCQX:RHHBF,SWX:ROG) for its drug candidate TPST-1120, which is targeting hepatocellular carcinoma, and Phase 1 clinical data for its TPST-1495 EP2/4 prostaglandin receptor antagonist, which is targeting multiple types of solid tumors.

4. Reneo Pharmaceuticals (NASDAQ:RPHM)

Year-to-date gain: 140.51 percent; market cap: US$140.09 million; current share price: US$5.70

Reneo Pharmaceuticals is a clinical-stage company working to develop and commercialize therapies for patients with rare genetic mitochondrial diseases. Its lead product candidate is mavodelpar, which has been shown to increase transcription of genes involved in mitochondrial function and increase fatty acid oxidation; it may also increase the production of new mitochondria.

In March, Reneo achieved the target enrollment for its STRIDE study of mavodelpar in primary mitochondrial myopathies. The company expects to put out top-line data in the fourth quarter and in 2024 will submit that data, along with long-term safety information, to the FDA and the European Medicines Agency (EMA).

5. Reata Pharmaceuticals (NASDAQ:RETA)

Year-to-date gain: 133.09 percent; market cap: US$3.33 billion; current share price: US$90.02

Texas-based Reata Pharmaceuticals is a biopharmaceutical company developing novel therapies for a variety of life-threatening chronic diseases with unmet therapeutic needs. The company’s pipeline targets molecular pathways involved in the regulation of cellular metabolism and inflammation.

Reata’s Skyclarys (omaveloxolone) recently received FDA approval for the treatment of Friedreich’s ataxia, a debilitating neuromuscular disease. The drug is under review by the EMA. The company is also developing bardoxolone methyl for the treatment of patients with chronic kidney disease and cemdomespib for the treatment of patients with diabetic neuropathic pain.

Don’t forget to follow us @INN_LifeScience for real-time news updates!

Securities Disclosure: I, Melissa Pistilli, hold no direct investment interest in any company mentioned in this article.

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